Novel Applications of Dermabond™ (2-Octyl -Cyanoacrylate) in Cardiothoracic Surgery
Omer Aziz, M.R.C.S., B.Sc.1
Clinical Research Fellow
M.S. Rahman, M.B., B.S.1
Foundation Year 2 Doctor
V.G. Hadjianastassiou, M.R.C.S.3
Specialist Registrar
John Kokotsakis, M.D.-1
Consultant Cardiothoracic Surgeon
Malinovski Vitali M.B.B.S.-2
Clinical Fellow
Ashok Cherian, M.D.-2
Consultant Cardiothoracic Surgeon
Ara Darzi, F.R.C.S., K.B.E.-1
Professor of Surgery
Thanos Athanasiou, Ph.D., F.E.T.C.S.-1,2
Senior Lecturer & Consultant Cardiothoracic Surgeon
1- Department of Biosurgery & Surgical Technology, St. Mary's Hospital, Imperial College, London, UK
2- Department of Cardiothoracic Surgery, St Mary's Hospital London, London, UK
3- Department of Vascular Surgery St Thomas Hospital London, London, UK
Dermabond™ (Ethicon Inc., Somerville, NJ, USA) is a cyanoacrylate adhesive normally indicated for skin wound closure. This study describes the emergency use of this adhesive to control bleeding close to coronary anastomoses in exceptional cases. Dermabond™ was used in 17 patients who underwent cardiac surgery during an eight-month period, where other haemostatic interventions were unsuitable. It was applied for haemorrhage in 15 patients and control air leaks in two of the patients. Haemostasis was successful with Dermabond™ alone in 11 patients; the remaining four required additional interventions. It effectively controlled haemorrhage from ventricular pacing wires, vascular sling holes, peri-anastomotic bleeding, and epicardial tears. The adhesive was not placed directly on any graft because of embolic risk. In the two patients with visible air leaks, it was successfully used. No patient events were recorded as a result of haemorrhage and no reported toxicity. Dermabond™ may be indicated in circumstances in which haemostasis with traditional methods has failed or is inappropriate. A need for further high-quality objective research exists on the effectiveness and long-term safety of 2-octyl cyanoacrylate in cardiac surgery.
